The growth of this discipline at UCI has been very rapid beginning with the formation of the Center for Biomedical Engineering in 1998. The Center was funded by a generous $3 million Development Award from the Whitaker Foundation to accelerate the growth of the formal educational and research opportunities in The Henry Samueli School of Engineering. In 2002, three major milestones were achieved including the formation of the Department of Biomedical Engineering, two undergraduate degree programs, and the expansion of the graduate program leading to the M.S. and Ph.D. degrees in biomedical engineering.
The future of biomedical engineering at UCI is bright. Our plan is to continue our expanding research horizons to include teams of researchers in four major clinical areas that include the neurosciences, ophthalmology, cardiology/cardiovascular science, and cancer. The former two compliment major areas of expertise and activity in UCI's College of Medicine whereas the latter two are an excellent match with Orange County's biomedical device industry. We invite you to explore the opportunities in biomedical engineering with us.
At the undergraduate level, the department offers a four-year engineering curriculum leading to a B.S. in Biomedical Engineering, which prepares students for a wide variety of careers in biomedical engineering including: industry, hospitals, research laboratories, or further education in graduate school.
A four-year engineering curriculum is available that together with required premedical courses, leads to a B.S. degree in Biomedical Engineering: Premedical. It is one of many majors that can serve as preparation for further training in medical, veterinary, or allied health professions. It is also suitable for students interested in pursuing graduate work in biomedical engineering, and other biomedical areas such a physiology, neurosciences and bioinformatics. The curriculum has less engineering content, and more of a biological sciences focus than the biomedical engineering major.
The sample program of study chart shown is typical for the major in Biomedical Engineering. Students should keep in mind that this program is based upon a sequence of prerequisites, beginning with adequate preparation in high school mathematics, physics, and chemistry. Students who are not adequately prepared, or who wish to make changes in the sequence for other reasons, must have their program approved by their faculty advisor. Biomedical Engineering majors must consult at least once every year with the academic counselors in the Student Affairs Office and with their faculty advisors.
|
Year |
Fall |
Winter |
Spring |
|
Freshman |
Math 2A (4) |
Math 2B (4) |
Math 2D (4) |
|
Sophomore |
Math 2J (4) |
Math 3D (4) |
BioSci 7 |
|
Junior |
BME 110A (4) |
BME 110B (4) |
BME 111 (4) |
|
Senior |
BME 180A (4) |
BME 180B (4) |
BME 160 (4)
|
The Biomedical Engineering Premedical curriculum provides future physicians with a quantitative background in biomechanics, bioelectronics, and biotransport. Such a background is increasingly important because of the heavy utilization of biomedical technology in modern medical practice. The curriculum includes courses in the sciences that satisfy the requirements of most medical schools. The education experience is enriched through a design course where students work as teams to solve Biomedical Engineering problems inspired by the clinical arena at the UCI Medical Center.
The sample program of study chart shown is typical for the major in Biomedical Engineering Premedical. Students should keep in mind that this program is based upon a sequence of prerequisites, beginning with adequate preparation in high school mathematics, physics, and chemistry. Students who are not adequately prepared, or who wish to make changes in the sequence for other reasons, must have their program approved by their faculty advisor. Biomedical Engineering Premedical majors must consult at least once every year with the academic counselors in the Student Affairs Office and with their faculty advisors.
Sample Program of Study – Biomedical Engineering |
|||
|
Year |
Fall |
Winter |
Spring |
|
Freshman |
Math 2A (4) |
Math 2B (4) |
Math 2D (4) |
|
Sophomore |
Math 2J (4) |
Math 3D (4) |
CHEM 51C (4) |
|
Junior |
BioSci 97 (4) |
BioSci 98 (4) |
BioSci 99 (4) |
|
Senior |
BioSci 100L (4) |
Bio Sci D103 or D104 (4) |
Bio Sci D111L (3) |
Private biomedical industry has indicated a keen interest in engineers that have a more traditional engineering degree (i.e. electrical engineering), but also possess some in-depth knowledge of biomedical systems. Hence, the minor in Biomedical Engineering is designed to provide a student with the introductory skills necessary to perform as an engineer in the biomedical arena.
Admissions: Students interested in the minor in Biomedical Engineering must apply through The Henry Samueli School of Engineering Student Affairs Office and must have a UCI cumulative GPA of 2.5 or higher.
NOTE: Students may not receive both a minor in Biomedical Engineering and a specialization in Biochemical Engineering within the Chemical Engineering major.
Requirements for the Minor in Biomedical Engineering
Mathematics Courses: Mathematics 2J and 3D
Engineering Topics Courses: BME1, BME50A-B, BME 120, BME 121
Technical Electives: Students select, with the approval of a faculty advisor, two technical elective courses from the following list:
BME110A
BME110B
BME130
BME135 (same as Biological Sciences 130)
BME136
BME136L
BME140
BME160
BME199
CBEMS124
CBEMS126
CBEMS154
EECS179
EECS188
The Biomedical Engineering graduate program at the University of California at Irvine is in The Henry Samueli School of Engineering and closely affiliated with the College of Medicine, School of Biological Sciences, and School of Physical Sciences. The program started in 1998 with the launch of the Center for Biomedical Engineering facilitated by a multi-million dollar Development Award from the Whitaker Foundation. There are currently 11 full-time faculty in the program and 43 joint appointments from the various schools listed above. Our research has core technologies in micro/nano medicine, biophotonics, biocomputation, and tissue engineering. The clinical emphases are neuroscience, cardiovascular diseases, cancer, and ophthalmology. There are three major degree options: Master of Science (M.S.), Doctor of Philosophy (Ph.D.), and the MD/Ph.D.
[Link to the General Catalogue
We are located in the heart of Orange County, the largest concentration of medical device companies in the nation. In addition, we are just 70 miles north of San Diego County, the nation's third largest concentration of biotech companies. The majority of our faculty collaborate and interact with these companies, providing a unique environment to perform relevant research addressing real-world concerns. It also provides for abundant opportunities to familiarize oneself with potential employers during the course of the graduate studies.
The faculty members in our program are relatively new and were selected specifically to focus on building up the core technologies and clinical research areas. You will find the research topics of our program to be at the cutting edge of their fields and the faculty members eager to work across boundaries. Our program's research in Biophotonics and Micro/Nano medicine are already widely recognized as among the top in the nation whilst the other areas are rapidly establishing themselves through the strength of the existing research accomplishments and the ongoing recruitment of world-class researchers. We have available to us the world-class facility at the Beckman Laser Institute for Biophotonics research. The Micro/Nano Medicine area boasts state-of-the-art facility at the Integrated Nanosystems Research Facility (INRF) and the California Institute for Telecommunications and Information Technology (Calit2).
Students admitted to the Ph.D. degree option are provided with a generous stipend and tuition/fee payments through the Whitaker Development Award. During the first year, the students are given the opportunity to rotate in up to three research labs under a "matching" process that allows the students to identify their eventual research advisor.
The Henry Samueli School of Engineering receives many more graduate applications than can be accommodated. Because of its interdisciplinary nature, Biomedical Engineering attracts students with a variety of backgrounds. Students should have a bachelors degree in either an engineering, physical science or biological science discipline.
Minimum coursework requirements for admission to the program will include the following:
Recommended requirements for admission are as follows:
| REQUIRED APPLICATION ITEMS |
An Application and $60 application fee, three (3) letters of recommendation, and official transcripts from all universities/colleges.
| GPA |
A GPA of 3.0 during the junior and senior years of undergraduate study is recommended for admission into the Biomedical Engineering program.
| Standardized Tests |
Minimum GRE scores of 1200 (quantitative plus verbal), or minimum combined MCAT scores in Verbal Reasoning, Physical Sciences, and Biological Sciences of 30 (a minimum score of 8 on each section) are recommended. In addition, a minimum score of 600 on the Test of English as a Foreign Language (TOEFL) is required of all international students whose native language is not English.
| TUITION/FEES |
| |
|
|
||||
| CA resident fees |
$2,439.50
|
|
$2,439.50
|
|
$2,438.50
|
|
|
|
|
|
|
|
||
| Non CA resident fees |
$2,409.50
|
|
$2,409.50
|
|
$2,408.50
|
|
| Non resident fees (paid by non-California residents) |
$3,859.00
|
|
$3,859.00
|
|
$3,860.00
|
|
|
Total Tuition and fees for |
$6,268.50
|
|
$6,268.50
|
|
$6,268.50
|
|
| |
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For those interested in taking Summer courses, please contact the UCI Extension program at www.unex.uci.edu.
| FINANCIAL VERIFICATION REQUIREMENT for INTERNATIONAL APPLICANTS |
International students must certify that they have support of approximately $30,806 per year for academic study to obtain a student visa. More information pertaining to this requirement is forwarded to international applicants upon acceptance.
| FINANCIAL AID |
For full financial aid consideration please have your application complete by February 1st!
The faculty in Biomedical Engineering are actively involved with many research projects. Most employ graduate student researchers, who work closely with faculty on various topics. Some of these positions provide financial assistance in the form of payment of fees, tuition, or a salary. Assistance varies from project to project. Your application will be considered for scholarship/assistantship when you indicate accordingly on the application itself.
Please note that admission to the university is separate from an offer of financial aid. In other words, you should not expect any financial assistance unless you are officially notified in writing of such an award by Biomedical Engineering. Such letters usually do not accompany the admission letter itself, but are sent a short time after the admission letter.
Exceptionally promising undergraduates at UCI may apply for admission through the accelerated M.S. and Ph.D. programs in the School of Engineering. This program is described in detail in the UCI general catalogue. However, these students must satisfy the coursework and letters of recommendation requirements as described above.
Deadline for completed applications is February 7 . This is the only application deadline for the entire year. Please review carefully our programs in research and courses. You may also contact individual faculty to learn about current research activities and possible opportunities for academic support. If you have a strong interest in our programs, you are welcome to apply using the procedure below.
Please file an electronic application over the Web.
The five digit application codes for Biomedical Engineering are:
Mail Supporting Materials:
Karen Stephens, BME Graduate Coordinator
Department of Biomedical Engineering
204 Rockwell Engineering Center
The Henry Samueli School of Engineering
University of California, Irvine
Irvine, CA 92697-2715
kstephen@uci.edu
Application Fee: All applications require a fee of $60. Your application will not be filed without this fee. No exceptions.
Biomedical Engineering was awarded a multi-million-dollar grant from the Whitaker Foundation in 1999. This prestigious award allows us to provide stipends for graduate and postdoctoral students, and allows us to further develop core resources in biophotonics, robotics, computational science and nanoscale systems.
We frequently receive questions early in the application process regarding the availability of support. We will not have the answers until your application has been completed and evaluated, at which time we will let you know immediately.
Foreign students, or students whose high school education was not English-based, cannot work as Teaching Assistants unless they pass the Test of Spoken English (TSE) with a minimum score of 50. The Web site of TSE indicates the dates of the exam.
Please read the Graduate Student handbook. This handbook provides helpful information to assist you in making a smooth transition as a new graduate student.
Thirty six (36) units of academic credit are required for the M.S. degree. This requirement will be met, in part, by the Graduate Biomedical Engineering Core (described below) of 22 units. The remaining (14 units) academic credits will be achieved through elective courses chosen by the student.
Option 1: Thesis A thesis option is available to students who prefer to conduct a focused research project. Students selecting this option must select a thesis advisor and complete an original research investigation including a written thesis, and obtain approval of the thesis by an thesis committee. A maximum of 8 M.S. research units (i.e. ECE 296) may be applied toward the 36 unit requirement.
Option II: Comprehensive Exam Alternatively, students may select a comprehensive exam option in which they must successfully complete 36 units of study and pass a comprehensive exam.
The Ph.D. in Biomedical Engineering requires the achievement of an original and significant body of research that advances the discipline, and which culminates in the oral and written presentation of a dissertation. Students may enter the Ph.D. program with a B.S. degree in engineering, biological science, or physical sciences from either UCI or another university. However, core skills in engineering mathematics must be demonstrated through previous graduate level coursework, or by taking a set of graduate courses at UCI that will be determined on a case-by-case basis by the Graduate Committee. Each student will be matched with a faculty advisor (from the list of Core and Affiliated faculty) and an individual program of study will be designed by the student and a faculty advisory committee. No additional graduate-level courses are required beyond that of the M.S. degree. Four milestones are required for the Ph.D.:
Advancement to candidacy must be completed between the 9th and 12th quarters of enrollment, usually the third academic year of the student. The qualifying exam is described in greater detail below. Special exceptions can be made, but a formal request with justification must be supplied in writing to the Director. The qualifying exam will consist of an oral and written presentation of original work completed thus far, and a coherent plan for completing a body of original research. The qualifying exam will be presented to the student’s graduate advisory committee. The graduate advisory committee will be selected by the student and faculty advisor and must have a minimum of five faculty members (including the faculty advisor). Of these five faculty members, a minimum of three must be affiliated biomedical engineering faculty. In addition, a minimum of two faculty members must have part of their primary appointment in the School of Engineering. The qualifying exam will follow campus and Henry Samueli School of Engineering guidelines.
The Ph.D. will be awarded upon submission of a written and an oral defense of an acceptable dissertation. The degree will be granted upon the recommendation of the graduate advisory committee and the Dean of Graduate Studies. Completion of the Ph.D is expected in the fifth year following completion of the B.S. degree, although a maximum of seven years (28 academic quarters) is allowed.
A combined M.D./Ph.D. degree is offered in conjunction with the UCI College of Medicine. The program combines clinical training and research experience. Students who complete this program will be awarded both an M.D. degree from the College of Medicine and a Ph.D. degree from the school of engineering. More information is available at the UCI Medical Scientist Training Program web page. Applications should be made to the UCI Medical Scientist Training Program and applicants should state that their chosen graduate department is Biomedical Engineering.
Thirty-six (36) units of academic credit are required for the M.S. degree. This requirement will be met, in part, by the Graduate Biomedical Engineering Core (described below) of 22 units. The remaining (14 units) academic credits will be achieved through elective courses chosen by the student.
Plan I: Thesis
A thesis option is available to students who prefer to conduct a focused research project. Students selecting this option must select a thesis advisor and complete an original research investigation including a written thesis, and obtain approval of the thesis by an thesis committee. A maximum of 8 M.S. research units (i.e. ECE 296) may be applied toward the 36 unit requirement.
Plan II: Comprehensive Examination Option
Alternatively, students may select a comprehensive exam option in which they must successfully complete 36 units of study and pass a comprehensive exam.
The Ph.D. in Biomedical Engineering requires the achievement of an original and significant body of research that advances the discipline, and which culminates in the oral and written presentation of a dissertation. Students may enter the Ph.D. program with a B.S. degree in engineering, biological science, or physical sciences from either UCI or another university. However, core skills in engineering mathematics must be demonstrated through previous graduate level coursework, or by taking a set of graduate courses at UCI that will be determined on a case-by-case basis by the Graduate Committee. Each student will be matched with a faculty advisor (from the list of Core and Affiliated faculty) and an individual program of study will be designed by the student and a faculty advisory committee. No additional graduate-level courses are required beyond that of the M.S. degree. Four milestones are required for the Ph.D.:
Advancement to candidacy must be completed between the 9th and 12th quarters of enrollment, usually the third academic year of the student. The qualifying exam is described in greater detail below. Special exceptions can be made, but a formal request with justification must be supplied in writing to the Director. The qualifying exam will consist of an oral and written presentation of original work completed thus far, and a coherent plan for completing a body of original research. The qualifying exam will be presented to the student's graduate advisory committee. The graduate advisory committee will be selected by the student and faculty advisor and must have a minimum of five faculty members (including the faculty advisor). Of these five (5) faculty members, three (3) must be core biomedical engineering faculty. In addition, one (1) faculty member must have his/her primary appointment outside the department of biomedical engineering and the fifth member must have his/her primary appointment outside of the
The Ph.D. will be awarded upon submission of a written and an oral defense of an acceptable dissertation. The degree will be granted upon the recommendation of the graduate advisory committee and the Dean of Graduate Studies. Completion of the Ph.D is expected in the fifth year following completion of the B.S. degree, although a maximum of seven years (28 academic quarters) is allowed.
A combined M.D./Ph.D. degree is offered in conjunction with the UCI College of Medicine. The program combines clinical training and research experience. Students who complete this program will be awarded both an M.D. degree from the
As part of the course requirements for the M.S. and Ph.D. degrees, all students will be required to take a set of core courses which total 22 units. A successful biomedical engineer is able to describe and analyze biomedical and biological systems in a quantitative fashion. Thus, at a minimum, a biomedical engineer must demonstrate competence in quantitative analysis, biological and biomedical structure and function, and an awareness of the clinical environment. Hence, the core courses cover the basics of cell and tissue (BME210) and sensory motor physiology (BME220) and organ transport physiology (BME221) and engineering mathematics (BME230A & 230B), and an introduction to clinical medicine (BME240). The core courses and descriptions are as follows:
The remaining course units (14 units) necessary to fulfill the course requirements for the M.S. and Ph.D. degree will be comprised of elective courses offered within the
BME 200: Introduction to Biomedical Engineering (Kassab) 2 units, Spring
BME 223: Advanced Cardiovascular Biomechanics (Kassab) 3 units, Spring
BME 261: Biomedical Microdevices I (Brody) 3 units, Fall
BME 262: Microfluidics (Jeon) 3 units, Winter
BME 263: Microsystem Technologies for Biomolecular Assays (A. Lee) 3 units, Winter
BME 295: Rendering Techniques for Biomedical Imaging (Meyer) 4 units, Winter
BME 295: Advanced Digital Image Processing (Meyer) 4 units, Spring
BME 295: Biomechanics (Kassab) 3 units, Fall
BME 295: Advanced Imaging (Chen) 3 units, Spring
BME 295: Advanced Biotechniques (Brody) 3 units, Winter
BME 295: Engineering Optics for Biomedical Applications (Tromberg) 3 units, Spring
BME 295: Biophotonics (Venugopalan) 3 units, Fall
Besides the formal lecture oriented courses that comprise the core and elective requirements, there are a series of special courses for which you will enroll in at various times during your study (see description below). These special course titles are listed below.
BME 295: Special Topics in Engineering (4-12 units – F, W,
Individual research or investigation conducted in preparation for the thesis required for the M.S. degree in Engineering. May be repeated for credit.
BME 297: Doctor of Philosophy Dissertation Research (4-12 units – F, W,
Individual research or investigation conducted in preparation for the dissertation required for the Ph.D. in Engineering. May be repeated for credit.
BME 298: Seminar in Biomedical Engineering (1 unit – F, W,
Presentation of advanced topics and reports of current research efforts in biomedical engineering. Required of all graduate students in the biomedical engineering program.
BME 299: Individual Research (1-12 units – F, W,
Individual research or investigation under the direction of an individual faculty member. Prerequisite: consent of instructor. (The course number will vary depending on which instructor you enroll with).
Q. Can the $60 application fee be waived?
A. No. It is against University policy to offer fee waivers.
Q. Is it easier to be admitted for the Fall, winter or spring quarter?
A. Applications are accepted for Fall quarter only. Under special circumstances, students may enroll in the Winter or Spring quarters only if they have a faculty sponsor in the department. Fellowships are only awarded in the Fall quarter.
Q. May I defer my admission offer?
A. Admitted students may be approved to defer admissions for up to one year. Deferral requests must be made in writing before the start of the original quarter of admission. Students may only defer once.
Q. My admission letter didn't include an offer of financial support. When will I hear about my financial support?
A. Every effort is made to make admission and financial support offers together for outstanding applicants. Sometimes candidates are admitted first and offered financial support later. In such cases the financial support offer is sent within two weeks of the admission offer. Every effort is made to offer financial aid by April 15th for the following fall. The department may make additional offers after April 15th subject to available funding.
A. Uniform admissions standards are applied to all students regardless of financial need.
Q. If I defer my offer of admission with financial support, what are my chances of being offered financial support again later?
A. The department will often approve admission and financial support deferral for one quarter only, from fall to winter. When the student defers admission from fall to fall, there is no guarantee that any financial support offer can be deferred as well. In such cases the student is again considered for financial support along with all others being offered admission for the same academic term.
Q. I received a fellowship for next academic year that includes a monthly stipend. Will I be required to work as a TA or a GSR in return for the stipend?
A. Conditions of your financial support award are included in the formal letter you received from the Department. Employment as a TA or GSR is not generally required when the student's financial support package includes a monthly stipend. When service is required in return for the stipend, the student is typically employed on a "without salary" basis as a Graduate Student Researcher.
Q. Why are TA salaries usually higher than GSR salaries for MS students and Ph.D. students who have not yet passed the qualifying examination?
A. GSRs and TAs are paid on different wage scales. The scale for most GSRs is lower than for TAs; however, fees and nonresident tuition for GSRs appointed to work at least 10 hours per week are paid in full. TAs are paid at a higher rate, but must pay a portion of their fees and nonresident tuition. The employment scale for a GSR can range from 25-49% time (10-19 hours per week); TAs are employed at 25% or 50% time (10 or 20 hours per week) only.
Q. Will my admission offer include guaranteed access to on-campus housing?
A. While a small number of our incoming students will be recommended for preferred placement in on-campus housing, it is not possible to provide guaranteed housing for all students who are admitted. All newly admitted students are responsible for applying on their own to live on campus; you will receive information direct from the UCI Housing Office concerning the various housing options available on campus. Early applications to live in on-campus housing are strongly encouraged; you do not need to wait to be admitted to apply to live on campus.
Deadline for completed applications is February 7 . This is the only application deadline for the entire year. Please review carefully our programs in research and courses. You may also contact individual faculty to learn about current research activities and possible opportunities for academic support. If you have a strong interest in our programs, you are welcome to apply using the procedure below.
Please file an electronic application over the Web.
The five digit application codes for Biomedical Engineering are:
Mail Completed Application Materials:
Karen Stephens, BME Graduate Coordinator
University of California, Irvine
Department of Biomedical Engineering
204 Rockwell Engineering Center
Irvine, CA 92697-2715
kstephen@uci.edu
Application Fee: All applications (electronic and paper ) require a fee of $60. Your application will not be filed without this fee. No exceptions.
Biomedical Engineering was awarded a multi-million-dollar grant from the Whitaker Foundation in 1999. This prestigious award allows us to provide stipends for graduate and postdoctoral students, and allows us to further develop core resources in biophotonics, robotics, computational science and nanoscale systems.
We frequently receive questions early in the application process regarding the availability of support. We will not have the answers until your application has been completed and evaluated, at which time we will let you know immediately.
Foreign students, or students whose high school education was not English-based, cannot work as Teaching Assistants unless they pass the Test of Spoken English (TSE) with a minimum score of 50. The TSE website indicates the dates of the exam.
Please read the Graduate Student Handbook. This handbook provides helpful information to assist you in making a smooth transition as a new graduate student.
Biomedical Computational Technologies
Beckman Laser Institute and Medical Clinic
Biotechnology Resource Facility
Chao Family Comprehensive Cancer Center
Integrated Nanosystems Research Facility (INRF)
Laboratory for Fluorescence Dynamics
Laser Microbeam and Medical Program
Biomedical computation in Biomedical Engineering will consist of three components: (1) image processing and pattern analysis, (2) data and knowledge base management, and (3) high-speed distributed computing of large data sets. These components will interact with one another while providing the enabling technologies for the analysis and utilization of the data produced by biomedical applications. Much of the data generated by biomedical systems appears in the form of signals (symbolic strings and waveforms), images, and, in general, arrays of vectors.
Part of the research effort required by biophotonics and nanoscale systems is in the area of computational models for the physical processes that generate the data. Research at UCI on computational models includes methods based on cubic and generalized spline approximation. Complementing the research on computational models for data generation is the UCI focus on pattern analysis. The objective is to develop application-specific algorithms for capturing and interpreting various complex patterns in the data.
Most biocomputational methods need to access and analyze large amounts of data. The data and information generated by such methods need to be tracked as time evolves. The nature of such scientific data/information demands the use of a powerful and intelligent database management system. Areas of current and future investigation include advanced data modeling, knowledge management, data mining, query optimization, and parallel/distributed processing of transactions.
Participating Faculty:
Pierre Baldi
Lubomir Bic
James Brody
Peter Burke
Zang-Hee Cho
Carl Cotman
Vittorio Cristini
Rui deFigueiredo
Steven George
Ghassan Kassab
Falko Kuester
Richard Lathrop
Thay Lee
Ray (Rui) Luo
Joerg Meyer
Sabee Molloi
Philip Sheu
Patrick Smyth
Much as microfabrication techniques have revolutionized the electronics industry, these same techniques are now poised to revolutionize the biotechnology and biomedical device industries. Photolithography, etching techniques, and deposition methods can create large numbers of microscopic features on silicon or glass substrates with areas of (greater than) 2 cm2.
Among these features are reaction chambers, separation channels, arrays of molecules, microelectronics, pumps, valves, and many other components. These features can be combined to create fully integrated devices that perform sample preparation, separation, detection and/or analysis, as well as drug delivery and in-situ mechanical sensors. The benefits of these integrated, miniaturized systems are their high-throughput screening capabilities, smaller required volumes of samples and reagents, and potential for automation with a consequent increase in reliability and decrease in costs.
The existing research strengths at UCI in genomics, cancer research, and protein technologies will be combined with those in MEMS (Micro-Electro-Mechanical Systems), microelectronics, and microelectrophoresis to develop new microdevices for biomedicine. Nanoscale technologies such as "lab-on-a-chip" devices, DNA array chips, chromosome microdissection/micromanipulation, and protein microanalysis techniques will be key technologies in the next century of biomedicine.
Participating Faculty:
Nancy Allbritton
Mark Bachman
Zhongping Chen
Steven Gross
Abraham P. Lee
G.P. Li
Noo Li
Jeon Marc Madou
Andrei M. Shkel
William Tang
Fan-Gang Zeng
Biophotonics involves the development and use of optical technologies to examine and manipulate biological systems on the sub-cellular, cellular, tissue and organ levels. The properties of photons and the systems that generate, deliver, and detect them will be the basis for much of the diagnostic, analytical, and therapeutic systems of the 21st century.
The ability to design, build and miniaturize non- and minimally-invasive systems will require a concerted interdisciplinary effort. The biomedical engineering efforts will be focused on the research and development necessary to: (1) produce the next generation of photonics-based medical devices, and (2) train biomedical engineers capable of spearheading such efforts.
These efforts are divided into three general core areas defined by photophysical mechanisms of light interaction with biological cells and tissues: (1) high-intensity interactions, (2) coherent interactions, and (3) diffuse interactions.
Participating Faculty
Michael Berns
Zhongping Chen
Ron Frostig
J. Stuart Nelson
Bruce Tromberg
Vasan Venugopalan
Brian Wong
The term "tissue engineering" was officially coined at a National Science Foundation workshop in 1988 to mean "the application of principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain or improve tissue function." Tissue engineering draws on experts from chemical engineering, materials science, surgery, genetics, and related disciplines from engineering and the life sciences.
Much of the current research in the field involves growing cells in three-dimensional structures instead of in laboratory dishes. For the most part, cells grown in a flat dish tend to behave as individual cells. But grow a cell culture in a three-dimensional structure, and the cells begin to behave as they would in a tissue or organ. Tissue engineers are testing different methods of growing tissue and organ cells in three-dimensional scaffolds that dissolve once the cells reach a certain mass. The hope is that these cell cultures will mature into fully functional tissues and organs.
Participating Faculty:
Peter Bryant
Jay Calvert
Gregory R.D. Evans
James Earthman
Steve George
Ranjan Gupta
Christopher Hughes
Noo Li Jeon
Ghassan Kassab
Shin Lin
Andrew Putnam
Bruce Tromberg
Michael Berns, Ph.D. Professor, Departments of Biomedical Engineering, Surgery, and Cell Biology
Research Interests: photomedicine, laser microscopy, biomedical devices
Email: mwberns@uci.edu
Visit Dr. Bern's Research Lab
James Brody, Ph.D. Assistant Professor, Department of Biomedical Engineering
Research Interests: Single molecule dynamics, bioinformatics, functional genomics, surface plasmon resonance.
Email: jpbrody@uci.edu
Visit Dr. Brody's Research Lab
Zhongping Chen, Ph.D. Professor, Department of Biomedical Engineering
Research Interests: microfabrication and fiber-optic based biomedical imaging systems development
Email: z2chen@uci.edu
Visit Dr. Chen's Research Lab
Vittorio Cristini, Ph.D. Assistant Professor, Department of Biomedical Engineering and
Department of Electrical Engineering and Computer Science
Research Interest: develop mathematical models and computer simulations of biological systems. Current focus is on cancer progression and treatment.
Email: cristini@math.uci.edu
Visit Dr. Cristini's Research Lab
Steven C. George, M.D., Ph.D. William J. Link Professor and Chair of Department of Biomedical Engineering and Professor in the Department of Chemical Engineering and Materials Sciences (ChEMS)
Research Interests: tissue engineering, prevascularization of implantable tissues, epithelial-mesenchymal cell communication, airway remodeling, wound healing, physiological systems modeling, and computational methods.
Email: scgeorge@uci.edu
Visit Dr. George's Research Lab
Enrico Gratton Professor, Biomedical Engineering
Email: egratton@uci.edu
Noo Li Jeon, Ph.D. Assistant Professor, Department of Biomedical Engineering
Research Interests: soft lithography in fabricating devices
Email: njeon@uci.edu
Visit Dr. Jeon's Research Lab
Tibor Juhasz, Ph.D. Professor, Department of Biomedical Engineering and Department of Ophthalmology
Research Interests: laser tissue remodeling and laser-cell interactions with particular interest in ophthalmic applications.
Email: tjuhasz@uci.edu
Ghassan Kassab, Ph.D. Professor, Department of Biomedical Engineering
Research Interests: vascular networks, coronary circulation in health and disease, tissue remodeling, simulation of biological systems
Email: gkassab@uci.edu
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Frithjof Kruggel, M.D. Professor, Biomedical Engineering
Research Interests: Signal and image processing for analysis of neurofunctional data (MRI, fMRI, PET, ERP, ERF), relation between structure and function in the human brain.
Email: fkruggel@uci.edu
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Abraham P. Lee, Ph.D. Professor, Department of Biomedical Engineering and
Integrated Nanosystems Research Facility, Electrical Engineering and Computer Science
Research Interests: Integrated micro and nano fluidic chip processors for the manipulation and self-assembly of biomolecules and other synthesized nanoparticles.
Email: aplee@uci.edu
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Joerg Meyer, Ph.D. Assistant Professor, Department of Biomedical Engineering and
Department of Electrical Engineering and Computer Science
Research Interests: large-scale biomedical imaging, interactive rendering of biological and medical data sets (CT/MRI/confocal laser-scan microscopy/cryosections), and biomolecular visualization (DNA/RNA/protein folding)
Email: jmeyer@uci.edu
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Zoran Nenadic D.Sc., Assistant Professor, Department of Biomedical Engineering
Research Interests: Adaptive biomedical signal processing, control algorithms for biomedical devices, brain-machine interfaces, modeling and analysis of biological neural networks
Email: znenadic@uci.edu
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Andrew Putnam, Ph.D., Assistant Professor, Department of Biomedical Engineering and
Department of Chemical Engineering and Materials Sciences (ChEMS)
Research Interests: Cell and tissue engineering, cellular signal transduction, biomaterials, integrins/cytoskeleton
Email: aputnam@uci.edu
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William C. Tang, Ph.D. Professor and Interim Chair, Department of Biomedical Engineering; Professor, Integrated Nanosystems Research Facility and Electrical Engineering and Computer Science; Director, Microbiomechanics Laboratory.
Research Interests: Micro- and nano-scale technology for biomedical implants and micro-scale biomechanics.
Email: wctang@uci.edu
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Bruce Tromberg, Ph.D. Professor, BLI and Department of Biomedical Engineering
Research Interests: photon interactions with biological systems, non-invasive fiber-optic sensors
Email: bjtrombe@uci.edu
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Nancy Allbritton, M.D., Ph.D. Professor, Department of Physiology and Biophysics
Research Interests: development of nanoscale systems to study intracellular signaling
Email: nlallbri@uci.edu
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Mark Bachman, Ph.D. Assistant Adjunct Professor, Department of Electrical Engineering and Computer Science
Research Interest: design and fabrication of microelectromechanical systems
Email: mbachman@uci.edu
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Pierre Baldi, Ph.D. Professor, Information & Computer Science.
Research Interests: bioinformatics/computational biology and probabilistic modeling/machine learning.
Email: pfbaldi@ics.uci.edu
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Lubomir Bic, Ph.D. Professor, Department of Information and Computer Science
Research Interests: distributed computing, parallel processing in biological systems
Email: lbic@uci.edu
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Bruce Blumberg, Ph.D. Assistant Professor, Department of Developmental and Cell Biology
Research Interests: biorobotics and functional genomics
Email: blumberg@uci.edu
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Peter Bryant, Ph.D. Professor, Development & Cell Biology
Research Interests: study of gene regulation and intercellular signaling during embryonic development used to regulate events during embryonic development and adult physiology
Email: pjbryant@uci.edu
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Peter Burke, Ph.D. Assistant Professor, Department of Electrical Engineering and Computer Science
Research Interests: quantum electronics and quantum information science
Email: pburke@uci.edu
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Jay Calvert, Ph.D. Assistant Professor, Department of Clinical Surgery
Research Interests: plastic surgery
Email: jcalvert@uci.edu
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Zang-Hee Cho, Ph.D. Professor, Department of Radiological Sciences
Research Interests: brain imaging
Email: zcho@uci.edu
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Carl Cotman, Ph.D. Professor, Departments of Psychobiology and Neurology
Research Interests: computational methods in brain aging, Alzheimer's disease
Email: cwcotman@uci.edu
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Nancy A. Da Silva, Ph.D. Professor, Chemical Engineering and Materials Science
Research Interests: molecular biotechnology, cloned gene expression, gene amplification and integration, metabolic engineering, and protein secretion, microbial degradation of toxic substances.
Email: ndasilva@uci.edu
Rui deFigueiredo, Ph.D. Research Professor, Department of Electrical and Computer Engineering
Research Interests: biomedical signal and image processing and pattern analysis
Email: rui@uci.edu
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James Earthman, Ph.D. Professor, Department of Chemical Engineering and Materials Sciences (ChEMS)
Research Interests: biomaterials, dental and orthopedic implants
Email: earthman@uci.edu
Gregory R.D. Evans, M.D. Professor, Department of Surgery
Research Interests: tissue engineering
Email: gevans@uci.edu
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Ron Frostig, Ph.D. Associate Professor, Department of Psychobiology
Research Interests: optical methods for brain imaging, functional organization of the cortex
Steve Gross, Ph.D. Assistant Professor, Department of Developmental and Cell Biology
Research Interests: in-vivo function of molecular motors, and optical tweezers
Email: sgross@uci.edu
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Zhibin Guan, Ph.D. Associate Professor, Department of Chemistry
Research Interests: Synthesis of new generation of biomaterials for gene/drug delivery and tissue regeneration.
Email: zguan@uci.edu
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Ranjan Gupta, Ph.D. Assistant Professor, Department of Orthopedic Surgery
Research Interests: In-vitro models for chronic nerve injury
Email: ranjang@uci.edu
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Christopher Hughes, Ph.D. Associate Professor, Department of Molecular Biology & Biochemistry
Research Interests: Endothelial cells as initiators and targets of immune responses and genes regulating endothelial cell tube formation/angiogenesis
Email: cchughes@uci.edu •
http://mbb.bio.uci.edu/home.html
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Joyce Keyak, Ph.D. Associate Professor, Department of Orthopedic Surgery, and Mechanical and Aerospace Engineering
Research Interests: orthopaedic biomechanics, bone mechanics, finite element analysis, quantitative computed tomography, and prosthesis design
Email: jhkeyak@uci.edu
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Falko Kuester, Ph.D. Assistant Professor, Electrical Engineering and Computer Science
Research Interests: scientific visualization, real-time computer graphics, virtual reality, collaborative virtual environments, distributed and remote visualization, biomedical imaging, computer aided geometric design
Email: fkuester@uci.edu
Baruch D. Kupperman, Ph.D. Associate Professor, Department of Ophthalmology
Research Interests: diabetic retinopathy, age-related macular degeneration, and the ocular complications of AIDS
Email: bdkupper@uci.edu
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Arthur D. Lander, M.D., Ph.D. Professor and Chair, Department of Developmental and Cell Biology
Research Interest: Cell Biology, Developmental Biology and Neurobiology, Cancer Biology and Computational Biology
Email: adlander@uci.edu
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Richard Lathrop, Ph.D. Associate Professor, Department of Information and Computer Science
Research Interests: computational methods in protein engineering
Email: rickl@uci.edu
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Thay Lee, Ph.D. Professor and Vice Chair for Research, Department of Orthopedic Surgery; Professor, Department of Biomedical Engineering
Research Interests: orthopedic biomechanics
Email: tqlee@uci.edu or tqlee@med.va.gov
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G.P. Li, Ph.D. Professor, Department of Electrical and Computer Engineering
Research Interests: design and fabrication of microelectromechanical systems
Email: gpli@uci.edu
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Shin Lin, Ph.D. Associate Vice Chancellor, Biomedical Initiatives, and
Professor of Biological Sciences and Physiology and Biophysics.
Research Interests: The combined use of biochemistry, cell biology, molecular biology, and molecular biophysics to study the structure and functions of proteins involved in cytoskeletal/contractile functions and signal transduction in muscle and nonmuscle cells.
Email: shinlin@uci.edu
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John Longhurst, M.D., Ph.D. Professor, Department of Medicine
Research Interests: Cardiology
Email: jcl@uci.edu
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Ray (Rui) Luo, Ph.D. Assistant Professor, Molecular Biology & Biochemistry
Research Interests: protein folding, protein structure and function prediction, molecular recognition, computational ligand screening by docking, molecular dynamics, continuum solvent models, free energy simulations, information technology in chemistry and biology Molecular Biology & Biochemistry
Email: rluo@uci.edu
Marc Madou, Ph.D. Professor, Department of Mechanical & Aerospace Engineering
Research Interests: Miniaturization science (MEMS and NEMS) with emphasis on chemical and biological applications.
Email: mmadou@uci.edu
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Sabee Molloi, Ph.D. Professor, Department of Radiological Sciences
Research Interests: digital radiography, application of digital subtraction angiography to cardiac imaging, coronary artery flow measurement, digital image processing.
Email: symolloi@uci.edu
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J. Stuart Nelson, M.D., Ph.D. Professor, Departments of Surgery and Dermatology
Research Interests: phototherapy and biomedical device development
Email: jsnelson@uci.edu
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David Reinkensmeyer, Ph.D. Assistant Professor, Department of Mechanical and Aerospace Engineering
Research Interests: skeletal muscle control, biorobotics, and rehabilitation
Email: dreinken@uci.edu
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Philip Sheu, Ph.D. Professor, Department of Electrical and Computer Engineering
Research Interests: biomedical database management, Intranet/Internet technologies
Email: